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TUBB3

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For Research Use Only. Not For Clinical Use.


Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance.
Protein class

Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Pancreatic endocrine cells, Inhibitory neurons, Excitatory neurons, Ductal cells, Gastric mucus-secreting cells, Exocrine glandular cells, Astrocytes)

Immune cell specificity

Immune cell enriched (naive B-cell)

Cell line specificity

Cell line enhanced (A549, SCLC-21H, SH-SY5Y)

Interaction

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with UNC5C (via cytoplasmic domain); this interaction is decreased by NTN1/Netrin-1 (PubMed:28483977). Interacts with NLRP5/MATER at cytoskeleton microtubules (PubMed:24374158). Interacts with DPYSL5 (PubMed:33894126).

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