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TNPO1
This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in several transcript variants encoding different proteins.
Protein class
Plasma proteins, Transporters
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Identified in a complex that contains TNPO1, RAN and RANBP1 (PubMed:9428644). Binds HNRPA1, HNRPA2, HNRNPDL, RPL23A, RPS7, RPL5, RAN and SRP19. Interacts with H2A, H2B, H3 and H4 histones (By similarity). Interacts with isoform 1 and isoform 5 of ADAR/ADAR1 (via DRBM 3 domain) (PubMed:19124606, PubMed:24753571). Interacts with SNAI1 (via zinc fingers); the interaction mediates SNAI1 nuclear import (PubMed:19386897). Interacts with SNAI2 (via zinc fingers) (PubMed:19386897). (Microbial infection) Binds to HIV-1 Rev.
More Types Infomation
- Mouse Anti-TNPO1 Recombinant Antibody (clone CBL912) (NEUT-2214CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, Neut, WB
- Mouse Anti-TNPO1 Recombinant Antibody (clone 2B6) (NEUT-2213CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, Neut, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC, IF, IHC, IP
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- Species Reactivity: Human
- Application: ELISA, ICC/IF, IHC-P, IP, WB
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- Species Reactivity: Mouse, Rabbit, Human, Monkey
- Type: Mouse IgG1
- Application: ELISA, IF, IHC-P, WB, IP
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For Research Use Only. Not For Clinical Use.