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    UCHL1

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    For Research Use Only. Not For Clinical Use.


    The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
    Protein class

    Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (Distal tubular cells, Excitatory neurons, Horizontal cells, Inhibitory neurons, Collecting duct cells, Spermatogonia)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Cell line enhanced (EFO-21, SCLC-21H, U-251 MG, U-266/84, U-87 MG)

    Interaction

    Monomer. Homodimer. Interacts with SNCA (By similarity). Interacts with COPS5.

    Molecular function

    Hydrolase, Protease, Thiol protease

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