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VDR
This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Nuclear receptors, Transcription factors, Transporters
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Distal enterocytes, Proximal enterocytes, Undifferentiated cells)
Immune cell specificity
Group enriched (non-classical monocyte, neutrophil, intermediate monocyte, myeloid DC, classical monocyte, eosinophil)
Cell line specificity
Cell line enhanced (HBEC3-KT, HDLM-2, U-937)
Interaction
Homodimer in the absence of bound vitamin D3 (PubMed:11980721). Heterodimer with RXRA after vitamin D3 binding (PubMed:15225774, PubMed:11980721, PubMed:10678179). Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes (PubMed:10866662, PubMed:15728261, PubMed:28698609, PubMed:9267036). Interacts with the corepressor NCOR1 (PubMed:28698609). Interacts with SNW1 (PubMed:9632709). Interacts with IRX4, the interaction does not affect its transactivation activity (PubMed:22323358). Interacts with CRY1 (By similarity). Interacts with CRY2 in a ligand-dependent manner (By similarity).
Molecular function
DNA-binding, Receptor
More Types Infomation
- Rabbit Anti-VDR Polyclonal Antibody (MRO-2275-CN) (MRO-2275-CN)
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, IF, FC
- Rabbit Anti-VDR Polyclonal Antibody (MRO-2274-CN) (MRO-2274-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, ELISA, IHC, IP
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP
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- Species Reactivity: Human
- Application: ICC/IF, WB
- Rabbit Anti-VDR Recombinant Antibody (clone JA11-16) (MRO-1588-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, FC
- Mouse Anti-VDR Recombinant Antibody; Fab Fragment (HPAB-1108-CN-F(E)) (HPAB-1108-CN-F(E))
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- Species Reactivity: Human, Rat
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-VDR Recombinant Antibody; scFv Fragment (HPAB-1108-CN-S(P)) (HPAB-1108-CN-S(P))
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- Species Reactivity: Human, Rat
- Type: Mouse scFv
- Application: ELISA
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, WB, IHC
- Mouse Anti-VDR Recombinant Antibody (VS3-CJ595) (VS3-CJ595)
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- Species Reactivity: Human
- Type: Mouse IgA
- Application: WB
- Mouse Anti-VDR Recombinant Antibody (HPAB-1108-CN) (HPAB-1108-CN)
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- Species Reactivity: Human, Rat
- Type: Mouse IgG
- Application: ELISA
- Recombinant Anti-mouse Vdr Intrabody [Tat] (IAB-B056(T))
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- Species Reactivity: mouse
- Type: scFv-Tat
- Application: FACS, ICC, FuncS
- Recombinant Anti-mouse Vdr Intrabody [+36 GFP] (IAB-B056(G))
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- Species Reactivity: mouse
- Type: scFv-(+36GFP)
- Application: FACS, ELISA, IF, FuncS
- Recombinant Anti-mouse Vdr Intrabody [(D-Arg)9] (IAB-B056(A))
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- Species Reactivity: mouse
- Type: scFv-(D-Arg)9
- Application: PCA, WB, FuncS
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For Research Use Only. Not For Clinical Use.