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VITAFT(α-D-GalNAc)EGLK

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For Research Use Only. Not For Clinical Use.


Background

The TCR structure of T cell hybridomas recognizing a tumor glycan-defined epitope has been studied using reverse transcriptase-PCR and gene sequencing. The hybridomas had been raised against a glycopeptide, T⁷²(Tn), consisting of the mouse hemoglobin-derived decapeptide Hb(67–76), O-glycoslated in position 72 with α-D-GalNAc. The glycan-specific hybridomas varied widely in their use of Vαgenes although V α4 was predominant, being present in one third of them. The V ggene usage was more restricted and dominated by Vβ1 and Vβ15.
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