VSV Peptide
Anti-VSV Peptide Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
The VSV peptide, corresponding to residues 52–59 from the nucleocapsid of the vesicular stomatitis virus, binds to H-2Kb, triggering a strong immune response mediated by cytotoxic CD8+ T cells. Previous analysis of VSV-specific CTL clones revealed the preferential usage of the Vβ13 and Vβ8 elements. Functional studies and analysis of the crystal structure of the H-2Kb/VSV complex have allowed the potential TCR-contact residues of the VSV peptide to be identified. In the present work, we asked how single amino acid replacements in TCR-exposed positions of the VSV peptide would affect the TCR repertoire of the responding CD8+ T cell population.