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WIPF1
Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (NK-cells, Oligodendrocytes, T-cells, monocytes, dendritic cells, Plasma cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Daudi, Karpas-707, U-266/70)
Interaction
Binds to WAS, profilin and actin. Binds to WASL (By similarity). Interacts with DBNL. Interacts with FNBP1L (via the SH3 domain) (PubMed:19798448).
Molecular function
Actin-binding
More Types Infomation
- Recombinant Anti-Human WIPF1 Antibody scFv Fragment (MOB-3675z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, FC, FuncS
- Recombinant Anti-Human WIPF1 Antibody Fab Fragment (MOB-3675z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: RIA, WB, FuncS
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, IHC-P, ELISA
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For Research Use Only. Not For Clinical Use.