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Anti-YWHAE Recombinant Antibody Products

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Anti-YWHAE Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs provides high-quality recombinant anti-YWHAE antibodies, expertly designed to support researchers and pharmaceutical companies. With a dedication to excellence and innovation, our products deliver exceptional performance, advancing biological and medical research worldwide.

YWHAE: A Promising Target for Cancer Therapy

YWHAE, or 14-3-3 epsilon, is a crucial phosphoserine-binding protein involved in diverse cellular processes, including signal transduction, cell cycle regulation, and neurodevelopment. Recent research highlights its aberrant expression in various cancers, acting as a proto-oncogene that promotes tumor proliferation and progression. Understanding YWHAE's intricate roles is paramount for developing novel diagnostic tools and effective therapeutic strategies against these diseases.

Alternative Names

14-3-3 protein epsilon; 14-3-3E; HEL2; KCIP-1; MDCR; MDS; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon.

Background

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]

Protein class

Cancer-related genes, Human disease related genes, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Homodimer (PubMed:17085597). Heterodimerizes with YWHAZ (PubMed:16376338). Interacts with PKA-phosphorylated AANAT (PubMed:11427721). Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm (PubMed:15696159). Interacts with ARHGEF28 (By similarity). Interacts with BEX3 (By similarity). Weakly interacts with CDKN1B (PubMed:12042314). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with DENND1A (PubMed:26055712). Interacts with GAB2 (PubMed:19172738). Interacts with phosphorylated GRB10 (PubMed:15722337). Interacts with KSR1 (PubMed:10409742). Interacts with NDEL1 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with the phosphorylated (by AKT1) form of SRPK2 (PubMed:19592491). Interacts with TIAM2. Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (By similarity). Interacts with ZFP36 (via phosphorylated form) (By similarity). Interacts with SLITRK1 (PubMed:19640509). Interacts with HSF1 (via phosphorylated form); this interaction promotes HSF1 sequestration in the cytoplasm in a ERK-dependent manner (PubMed:12917326). Interacts with RIPOR2 isoform 2 (PubMed:25588844). Interacts with KLHL22; required for the nuclear localization of KLHL22 upon amino acid starvation (PubMed:29769719). Interacts with CRTC1 (PubMed:30611118). Interacts with CRTC2 (probably when phosphorylated at 'Ser-171') (PubMed:30611118). Interacts with CRTC3 (probably when phosphorylated at 'Ser-162' and/or 'Ser-273') (PubMed:30611118). Interacts with ATP2B1 and ATP2B3; this interaction inhibits calcium-transporting ATPase activity (PubMed:18029012). Interacts with MEFV (PubMed:27030597). (Microbial infection) Interacts with HCV core protein.

More Types Infomation

Anti-YWHAE rAb Products

Our anti-YWHAE recombinant antibody products are engineered with superior precision, offering exceptional advantages for your research. Utilizing advanced recombinant technology, these antibodies provide high homogeneity, batch-to-batch reproducibility, and reduced background noise, ensuring reliable and consistent results. Their enhanced specificity minimizes off-target binding, crucial for accurate detection and validation in complex biological systems.

Cat. No. Product Name Target Species Host Species Applications
MOB-2172MZ Recombinant Mouse Anti-Human YWHAE Antibody (clone 6B6) Human Mouse antibody ELISA, WB
VS3-CJ1087 Rabbit Anti-YWHAE Recombinant Antibody (VS3-CJ1087) Human, Mouse, Rat Rabbit IgG WB, ICC, IF, IHC, FC
MOB-2866z Mouse Anti-YWHAE Recombinant Antibody (clone 30A1) Human Mouse IgG2b ELISA, WB
TAB-0606CLV Mouse Anti-YWHAE Recombinant Antibody (TAB-0606CLV) No species cross-reactivity Mouse IgG ELISA
MOR-3905 Rabbit Anti-YWHAE Recombinant Antibody (clone DS3905AB) Human Rabbit IgG WB, ICC, FC

Table 1. Featured anti-YWHAE recombinant antibody products at Creative Biolabs.

Creative Quality Control

At Creative Biolabs, rigorous quality control is embedded in every step of our anti-YWHAE recombinant antibody production. We employ a multi-faceted approach, including ELISA, Western Blot, flow cytometry, and immunofluorescence, to guarantee optimal specificity, affinity, and functional validation. This stringent quality assurance ensures that each antibody meets the highest performance standards, providing you with confidence in your experimental outcomes.

Customer Reviews

Excellent
Ja***i
Rabbit Anti-YWHAE Recombinant Antibody (clone DS3905AB) (MOR-3905)
The anti-YWHAE recombinant antibody from Creative Biolabs significantly enhanced our user experience. Its clear instructions and robust performance streamlined our workflow, allowing us to achieve reliable results much faster than anticipated. A truly superior product!
15/Dec/2024
Excellent
Mi***y
Mouse Anti-YWHAE Recombinant Antibody (clone 30A1) (MOB-2866z)
For our therapeutic development, the application of this anti-YWHAE antibody has been invaluable. Its high specificity allowed us to precisely target and validate YWHAE in our in vivo models, accelerating our understanding of disease mechanisms. Highly recommended for advanced research.
25/Feb/2025
Excellent
Kr***n
Rabbit Anti-YWHAE Recombinant Antibody (clone CBACN-003) (MRO-0005-CN)
We've incorporated Creative Biolabs' anti-YWHAE antibody into multiple assays, and its usage experience has been exceptional. The consistency across batches is remarkable, leading to highly reproducible data in our Western Blot and IHC experiments. It's become a staple in our lab.
12/Aug/2025

rAb Production

Our anti-YWHAE recombinant antibody products are generated using state-of-the-art recombinant antibody production platforms. This allows for rapid screening and selection of high-affinity binders, ensuring a diverse range of antibody candidates. Subsequent optimization and large-scale production in mammalian cells deliver antibodies with superior purity and consistent performance.

Featured Anti-YWHAE Recombinant Antibody Production PlatformsMilligram-scale. (Creative Biolabs Original)
Fig.1 Milligram-scale anti-YWHAE recombinant antibody production.

Gram-scale. (Creative Biolabs Original)Fig.2 Gram-scale anti-YWHAE recombinant antibody production.

rAb Modalities

Creative Biolabs offers anti-YWHAE recombinant antibodies in multiple modalities, including unconjugated, biotinylated, and fluorescently labeled formats, providing versatility for various research applications.

YWHAE antibody production and modalities. (Creative Biolabs Original)Fig.3 Full-length anti-YWHAE recombinant antibody production and modalities.

Discover how Creative Biolabs' advanced anti-YWHAE recombinant antibody products can accelerate your scientific breakthroughs. Our dedicated team is ready to support your research needs with unparalleled product quality and expertise. Get in touch with us today to learn more about our comprehensive solutions and discuss how we can partner to achieve your research and development goals.

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