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ZHX2
Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA.
Protein class
Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Group enriched (Astrocytes, Oligodendrocyte precursor cells, Oligodendrocytes, Microglial cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Daudi, REH, U-698)
Interaction
Homodimer (via homeobox domain) (PubMed:12741956, PubMed:14659886). Heterodimer with ZHX1 (via homeobox domain 1) (PubMed:12741956). Heterodimer with ZHX3 (via homeobox domain 1) (PubMed:12741956, PubMed:14659886). Heterodimerization with ZHX1 is not necessary for repressor activity (PubMed:12741956). Interacts (via homeobox domain) with NFYA (via N-terminus) (PubMed:12741956). Interacts with EFNB1 intracellular domain peptide; the interaction enhances ZHX2 transcriptional repression activity (By similarity).
Molecular function
DNA-binding, Repressor
More Types Infomation
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- Species Reactivity: Human
- Application: IHC-P, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, IP, IF, ELISA
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For Research Use Only. Not For Clinical Use.