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ABCC4

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants.
Protein class

Enzymes, Metabolic proteins, Plasma proteins, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Microglial cells, granulocytes, Erythroid cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Group enriched (HEL, HMC-1, RPTEC TERT1)

Interaction

Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); this interaction accelerates MRP4 internalization.

Molecular function

Translocase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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