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ADAMTS10

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.
Protein class

Disease related genes, Human disease related genes

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Microglial cells, Excitatory neurons, Inhibitory neurons, Astrocytes, Skeletal myocytes, Smooth muscle cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (HeLa, hTERT-RPE1, NB-4, REH)

Interaction

Interacts with FBN1; this interaction promotes microfibrils assembly.

Molecular function

Hydrolase, Metalloprotease, Protease

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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