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AIMP1
AIMP1 is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. AIMP1 is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer. Part of the multisynthetase complex (MSC), a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:24312579, PubMed:19131329, PubMed:19289464). Interacts (via N-terminus) with RARS1 (via N-terminus) (PubMed:10358004, PubMed:17443684). Part of a complex composed of RARS1, QARS1 and AIMP1 (PubMed:25288775). Interacts (via C-terminus) with SMURF2. Interacts (via N-terminus) with HSP90B1/gp96 (via C-terminus) (By similarity). Interacts with PSMA7 (PubMed:19362550). Interacts with TARS3 (PubMed:24312579).
Molecular function
Cytokine, RNA-binding, tRNA-binding
More Types Infomation
- Mouse Anti-AIMP1 Recombinant Antibody (clone 1C11) (MOB-0645CT)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, WB
- Rat Anti-AIMP1 Recombinant Antibody; scFv Fragment (HPAB-0344-YJ-S(P)) (HPAB-0344-YJ-S(P))
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- Species Reactivity: Human
- Type: Rat scFv
- Application: ELISA, IF, Neut
- Rat Anti-AIMP1 Recombinant Antibody (HPAB-0344-YJ) (HPAB-0344-YJ)
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- Species Reactivity: Human
- Type: Rat IgG
- Application: ELISA, WB, Inhib, FuncS
- Rat Anti-AIMP1 Recombinant Antibody; Fab Fragment (HPAB-0344-YJ-F(E)) (HPAB-0344-YJ-F(E))
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- Species Reactivity: Human
- Type: Rat Fab
- Application: ELISA, IF, Neut
- Chicken Anti-SCYE1 Polyclonal IgY (BRD-0526MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.