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AKAP13

Engineered Antibody scTCR
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta.
Protein class

Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (HMC-1)

Interaction

Interacts with the cAMP-dependent protein kinase (PKA) holoenzyme and with the regulatory subunit PRKAR2A (PubMed:11546812, PubMed:1618839, PubMed:15229649, PubMed:21102438, PubMed:11285229). Interacts with RHOA (PubMed:11546812, PubMed:17537920, PubMed:25186459, PubMed:24993829). Interacts also with RHOB and RHOC (PubMed:11546812). Identified in a ternary complex with RHOA and PRKAR2A (PubMed:11546812). Identified in a complex with NR3C1 and RHOA (PubMed:16469733). Interacts with BRAF and KSR1 (PubMed:21102438). Identified in a complex with BRAF and KSR1 (PubMed:21102438). Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381). Interacts (phosphorylated form) with YWHAB and YWHAZ (PubMed:15229649, PubMed:21224381). Interaction with YWHAB inhibits activation of RHOA, interferes with PKN1 binding and activation of MAP kinases (PubMed:15229649, PubMed:21224381). Interacts with GNA12 (PubMed:11546812). Interacts with IKBKB (PubMed:23090968). Interacts with ESR1, THRA, PPARA and NME2 (PubMed:9627117, PubMed:15249197). Interacts (via the C-terminal domain after the PH domain) with MEF2C and RXRB. Interacts (via the C-terminal domain after the PH domain) with PRKD1 (By similarity).

Molecular function

Guanine-nucleotide releasing factor

More Types Infomation
Related Signaling Pathways
cAMP Signaling Pathway cAMP Signaling Pathway

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