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AKR1B1
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]
Protein class
Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Syncytiotrophoblasts, Extravillous trophoblasts, Cytotrophoblasts, Ionocytes, Collecting duct cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (A549, BJ hTERT+, RPTEC TERT1, U-87 MG)
Interaction
Monomer.
Molecular function
Oxidoreductase
More Types Infomation
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, IHC, WB
- Mouse Anti-AKR1B1 Recombinant Antibody (clone 2) (MOB-0559MZ)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, WB
-
- Species Reactivity: Human, Mouse, Dog, Rabbit
- Type: Mouse IgG
- Application: WB
-
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1
- Application: WB
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For Research Use Only. Not For Clinical Use.