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AMN
The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila.
Protein class
Disease related genes, Human disease related genes, Metabolic proteins
Predicted location
Intracellular, Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Proximal enterocytes, Paneth cells, Distal enterocytes, Proximal tubular cells, Intestinal goblet cells, Undifferentiated cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BEWO, CACO-2, Hep G2, U-698)
Interaction
Interacts (via extracellular region) with CUBN/cubilin, giving rise to a huge complex containing one AMN chain and three CUBN chains.
Molecular function
Developmental protein
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: WB, IP
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For Research Use Only. Not For Clinical Use.