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ANXA1

This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
Protein class

Cancer-related genes, FDA approved drug targets, Plasma proteins, Transporters

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Syncytiotrophoblasts, Urothelial cells, Squamous epithelial cells)

Immune cell specificity

Immune cell enhanced (basophil)

Cell line specificity

Low cell line specificity

Interaction

Homodimer; non-covalently linked (By similarity). Homodimer; linked by transglutamylation (PubMed:2532504). Homodimers linked by transglutamylation are observed in placenta, but not in other tissues (PubMed:2532504). Interacts with S100A11 (PubMed:8557678, PubMed:10673436). Heterotetramer, formed by two molecules each of S100A11 and ANXA1 (PubMed:10673436). Interacts with DYSF (By similarity). Interacts with EGFR (By similarity).

Molecular function

Phospholipase A2 inhibitor

More Types Infomation

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