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APOC1

This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Metabolic proteins, Plasma proteins

Predicted location

Secreted

Single cell type specificity

Cell type enriched (Hepatocytes)

Immune cell specificity

Immune cell enriched (myeloid DC)

Cell line specificity

Cell line enhanced (Hep G2, HSkMC, K-562, SK-MEL-30)

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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