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ARL2

This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes.
Protein class

FDA approved drug targets

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Late spermatids, Proximal tubular cells, Early spermatids)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Found in a complex with ARL2, ARL2BP and SLC25A6 (PubMed:30945270). Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Found in a complex with ARL2, ARL2BP and SLC25A4. The GTP-bound form interacts with PDE6D. Interacts with ELMOD2. The GTP-bound form interacts with ARL2BP. Interacts, preferentially in its GDP-bound state, with TBCD (PubMed:10488091, PubMed:10831612, PubMed:11303027, PubMed:11847227, PubMed:17452337, PubMed:18234692, PubMed:18981177, PubMed:19368893, PubMed:27666374). Interacts with UNC119.

More Types Infomation

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