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B2M
β2 microglobulin also known as B2M is a component of MHC class I molecules, MHC class I molecules have α1, α2, and α3 proteins which are present on all nucleated cells (excludes red blood cells). In humans, the β2 microglobulin protein is encoded by the B2M gene.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Transporters
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (monocytes, NK-cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M alone (not in complex with HLA-I) interacts with M.tuberculosis EsxA (ESAT-6) and an EsxA-EsxB (CFP-10) complex; the tripartite complex can be detected in the host endoplasmic reticulum (PubMed:25356553). The B2M-EsxA complex can be detected in patients with pleural tuberculosis and is stable from pH 4.0 to 8.0 and in the presence of 2M NaCl (PubMed:25356553). Forms a heterotrimer with HLA-E and a self- or a foreign peptide (PubMed:9427624). Forms a heterotrimer with HLA-G and a self-peptide (PubMed:17056715). Forms a heterotrimer with HLA-F and a self-peptide (PubMed:10605026). Forms a heterotrimer with MR1 and a metabolite antigen.
More Types Infomation
- PE-H2-IAd/Human B2M (ACRVNHVTLSQPKIVK) MHC Tetramer (MHC-LC2379)
-
- Class: Class II
- Antigen: B2M
- Antigen Species: Human
- Peptide: ACRVNHVTLSQPKIVK
- Conjugate: PE
- PE-H2-IEd/Human B2M (ACRVNHVTLSQPKIVK) MHC Tetramer (MHC-LC2380)
-
- Class: Class II
- Antigen: B2M
- Antigen Species: Human
- Peptide: ACRVNHVTLSQPKIVK
- Conjugate: PE
-
- Class: Class II
- Antigen: B2M
- Antigen Species: Human
- Peptide: ACRVNHVTLSQPKIVK
- Conjugate: PE
-
- Class: Class II
- Antigen: B2M
- Antigen Species: Human
- Peptide: ACRVNHVTLSQPKIVK
- Conjugate: PE
- PE-H2-IAd/Human B2M (CYVSGFHPSDIEVDLL) MHC Tetramer (MHC-LC2383)
-
- Class: Class II
- Antigen: B2M
- Antigen Species: Human
- Peptide: CYVSGFHPSDIEVDLL
- Conjugate: PE
- PE-H2-IEd/Human B2M (GERIEKVEHSDLSFSY) MHC Tetramer (MHC-LC2384)
-
- Class: Class II
- Antigen: B2M
- Antigen Species: Human
- Peptide: GERIEKVEHSDLSFSY
- Conjugate: PE
-
- Class: Class II
- Antigen: B2M
- Antigen Species: Human
- Peptide: HPAENGKSNFLNCYVS
- Conjugate: PE
- PE-H2-IAd/Human B2M (HPSDIEVDLLKDGERI) MHC Tetramer (MHC-LC2386)
-
- Class: Class II
- Antigen: B2M
- Antigen Species: Human
- Peptide: HPSDIEVDLLKDGERI
- Conjugate: PE
- PE-H2-IAd/Human B2M (IQRTPKIQVYSRHPAE) MHC Tetramer (MHC-LC2387)
-
- Class: Class II
- Antigen: B2M
- Antigen Species: Human
- Peptide: IQRTPKIQVYSRHPAE
- Conjugate: PE
- PE-H2-IEd/Human B2M (IQRTPKIQVYSRHPAE) MHC Tetramer (MHC-LC2388)
-
- Class: Class II
- Antigen: B2M
- Antigen Species: Human
- Peptide: IQRTPKIQVYSRHPAE
- Conjugate: PE
-
- Class: Class II
- Antigen: B2M
- Antigen Species: Human
- Peptide: IQRTPKIQVYSRHPAE
- Conjugate: PE
-
- Class: Class II
- Antigen: B2M
- Antigen Species: Human
- Peptide: IQRTPKIQVYSRHPAE
- Conjugate: PE
-
- Class: Class II
- Antigen: B2M
- Antigen Species: Human
- Peptide: IQRTPKIQVYSRHPAE
- Conjugate: PE
- PE-H2-IAd/Human B2M (IQVYSRHPAENGKSNF) MHC Tetramer (MHC-LC2392)
-
- Class: Class II
- Antigen: B2M
- Antigen Species: Human
- Peptide: IQVYSRHPAENGKSNF
- Conjugate: PE
- PE-H2-IEd/Human B2M (IQVYSRHPAENGKSNF) MHC Tetramer (MHC-LC2393)
-
- Class: Class II
- Antigen: B2M
- Antigen Species: Human
- Peptide: IQVYSRHPAENGKSNF
- Conjugate: PE
-
- Class: Class II
- Antigen: B2M
- Antigen Species: Human
- Peptide: IQVYSRHPAENGKSNF
- Conjugate: PE
-
- Class: Class II
- Antigen: B2M
- Antigen Species: Human
- Peptide: IQVYSRHPAENGKSNF
- Conjugate: PE
-
- Class: Class II
- Antigen: B2M
- Antigen Species: Human
- Peptide: IQVYSRHPAENGKSNF
- Conjugate: PE
- PE-H2-IAd/Human B2M (KSNFLNCYVSGFHPSD) MHC Tetramer (MHC-LC2397)
-
- Class: Class II
- Antigen: B2M
- Antigen Species: Human
- Peptide: KSNFLNCYVSGFHPSD
- Conjugate: PE
- PE-H2-IEd/Human B2M (KSNFLNCYVSGFHPSD) MHC Tetramer (MHC-LC2398)
-
- Class: Class II
- Antigen: B2M
- Antigen Species: Human
- Peptide: KSNFLNCYVSGFHPSD
- Conjugate: PE
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For Research Use Only. Not For Clinical Use.