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BCHE

This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits broad substrate specificity and is involved in the detoxification of poisons including organophosphate nerve agents and pesticides, and the metabolism of drugs including cocaine, heroin and aspirin. Humans homozygous for certain mutations in this gene exhibit prolonged apnea after administration of the muscle relaxant succinylcholine. [provided by RefSeq, Jul 2016]
Protein class

Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Group enriched (Hepatocytes, Oligodendrocyte precursor cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (Karpas-707)

Interaction

Homotetramer; disulfide-linked. Dimer of dimers.

Molecular function

Hydrolase, Serine esterase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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