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BMI1
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.
Protein class
Cancer-related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids, Early spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HDLM-2, U-937)
Interaction
Component of a PRC1-like complex (PubMed:12167701, PubMed:15386022, PubMed:19636380, PubMed:21282530, PubMed:26151332, PubMed:21772249, PubMed:25355358). Identified in a PRC1-like HPRC-H complex with CBX2, CBX4, CBX8, PHC1, PHC2, PHC3 RING1 and RNF2 (PubMed:12167701). Interacts with RNF2/RING2 (PubMed:16714294, PubMed:21772249, PubMed:25355358). Interacts with RING1 (By similarity). Part of a complex that contains RNF2, UB2D3 and BMI1, where RNF2 and BMI1 form a tight heterodimer, and UB2D3 interacts only with RNF2 (PubMed:21772249, PubMed:25355358). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). Interacts with CBX7 and CBX8 (PubMed:19636380). Interacts with SPOP (PubMed:15897469). Part of a complex consisting of BMI1, CUL3 and SPOP (PubMed:15897469). Interacts with E4F1 (PubMed:16882984). Interacts with PHC2 (PubMed:9121482, PubMed:9199346, PubMed:27827373). Interacts with zinc finger protein ZNF277 (By similarity). May be part of a complex including at least ZNF277, BMI1 and RNF2/RING2 (By similarity).
Molecular function
Chromatin regulator, Repressor
More Types Infomation
- FITC-A*02:01/Human BMI1 (TLQDIVYKL) MHC Tetramer (MHC-CN0451)
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- Class: Class I
- Antigen: BMI1
- Antigen Species: Human
- Peptide: TLQDIVYKL
- Conjugate: FITC
- APC-A*02:01/Human BMI1 (TLQDIVYKL) MHC Tetramer (MHC-CN0450)
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- Class: Class I
- Antigen: BMI1
- Antigen Species: Human
- Peptide: TLQDIVYKL
- Conjugate: APC
- PE-A*02:01/Human BMI1 (TLQDIVYKL) MHC Tetramer (MHC-CN0449)
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- Class: Class I
- Antigen: BMI1
- Antigen Species: Human
- Peptide: TLQDIVYKL
- Conjugate: PE
- PE-A*02:01/Human BMI1 (CLPSPSTPV) MHC Tetramer (MHC-CN0453)
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- Class: Class I
- Antigen: BMI1
- Antigen Species: Human
- Peptide: CLPSPSTPV
- Conjugate: PE
- A*02:01/Human BMI1 (TLQDIVYKL) MHC Tetramer (MHC-CN0452)
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- Class: Class I
- Antigen: BMI1
- Antigen Species: Human
- Peptide: TLQDIVYKL
- Conjugate: Unconjugated
- A*02:01/Human BMI1 (TLQDIVYKL) MHC Pentamer (MHC-YF338)
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- Class: Class I
- Antigen: BMI1
- Antigen Species: Human
- Peptide: TLQDIVYKL
- Conjugate: Unlabeled, Biotin, R-PE, APC
- A*02:01/Human BMI1 (CLPSPSTPV) MHC Pentamer (MHC-YF337)
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- Class: Class I
- Antigen: BMI1
- Antigen Species: Human
- Peptide: CLPSPSTPV
- Conjugate: Unlabeled, Biotin, R-PE, APC
- APC-A*02:01/Human BMI1 (CLPSPSTPV) MHC Tetramer (MHC-CN0454)
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- Class: Class I
- Antigen: BMI1
- Antigen Species: Human
- Peptide: CLPSPSTPV
- Conjugate: APC
- FITC-A*02:01/Human BMI1 (CLPSPSTPV) MHC Tetramer (MHC-CN0455)
-
- Class: Class I
- Antigen: BMI1
- Antigen Species: Human
- Peptide: CLPSPSTPV
- Conjugate: FITC
- A*02:01/Human BMI1 (CLPSPSTPV) MHC Tetramer (MHC-CN0456)
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- Class: Class I
- Antigen: BMI1
- Antigen Species: Human
- Peptide: CLPSPSTPV
- Conjugate: Unconjugated
- Mouse Anti-BMI1 Recombinant Antibody (clone EML250) (MOB-0263CT)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
- Mouse Anti-BMI1 Recombinant Antibody (clone B3-G5) (MRO-0186-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG2a
- Application: WB, IF, IHC, FC
- Rabbit Anti-BMI1 Recombinant Antibody (clone CBACN-072) (MRO-0185-CN)
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
- Mouse Anti-BMI1 Recombinant Antibody (clone A11-C11) (MRO-0184-CN)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG2a
- Application: WB, IHC, IF
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, FC, ICC, IF, IHC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, ICC
- Mouse Anti-BMI1 Recombinant Antibody (clone 3E3) (VS3-XY128)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC, FC, ICC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
-
- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC
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