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BST2

Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis.
Protein class

CD markers, Plasma proteins, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Adipocytes, Theca cells, Hepatic stellate cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, Karpas-707)

Interaction

Parallel homodimer; disulfide-linked. May form homotetramers under reducing conditions. Isoform 1 and isoform 2 form homodimers and also heterodimers with each other. Dimerization is essential for its antiviral activity (PubMed:26378163, PubMed:10329429, PubMed:19737401, PubMed:19879838, PubMed:23028328, PubMed:20399176, PubMed:20880831, PubMed:20940320, PubMed:31199522). Interacts (via cytoplasmic domain) with ARHGAP44 (By similarity). Interacts with MMP14 (via C-terminal cytoplasmic tail) (PubMed:22065321). Interacts with LILRA4/ILT7 (PubMed:19564354). (Microbial infection) Interacts with ebola GP protein. (Microbial infection) Interacts (via transmembrane domain) with HIV-1 VPU (via transmembrane domain). (Microbial infection) Interacts with HIV-2 ENV. (Microbial infection) Interacts with SARS-CoV ORF7a protein.

More Types Infomation

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