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BTN3A3

The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A3) genes, which have undergone tandem duplication, resulting in 3 copies of each.
Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (NK-cells, Plasma cells, T-cells, dendritic cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (ASC TERT1, BJ hTERT+ SV40 Large T+ RasG12V)

Interaction

Homodimer.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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