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C9
This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Cell type enriched (Hepatocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (JURKAT)
Interaction
Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9 (PubMed:22832194). About 20 C9 chains oligomerize to give rise to a huge beta-barrel that forms a 100 Angstrom diameter pore in target membranes (PubMed:26841934, 30111885).
More Types Infomation
Related Diseases
Systemic Lupus Erythematosus
- Mouse Anti-C9 Recombinant Antibody (clone bE12) (MOB-0266MZ)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: IHC
- Mouse Anti-C9 Recombinant Antibody (clone 6H12) (MOB-3829z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, ICC, IF, IHC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, IP
- Mouse Anti-C9 Recombinant Antibody (clone 64) (MOB-2274MZ)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, IHC-P, WB
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For Research Use Only. Not For Clinical Use.