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CA12

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas.
Protein class

Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Distal enterocytes, Suprabasal keratinocytes, Squamous epithelial cells, Basal keratinocytes, Paneth cells, Undifferentiated cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (A549, ASC TERT1, RT4, SK-BR-3, T-47d, U-138 MG, U-87 MG)

Interaction

Homodimer.

Molecular function

Lyase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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