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CACNB3
This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]
Protein class
FDA approved drug targets, Transporters
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Endometrial stromal cells)
Immune cell specificity
Immune cell enhanced (T-reg)
Cell line specificity
Cell line enhanced (hTERT-RPE1, U-937)
Interaction
Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1C) and the ancillary subunits CACNB3 and CACNA2D1 (PubMed:29742403). The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio (Probable). Interacts with CACNA2D4 (PubMed:12181424). Interacts with FASLG (PubMed:19807924). Interacts with CBARP; prevents the interaction of CACNB3 with the alpha subunit CACNA1C thereby negatively regulating the activity of the corresponding calcium channel (By similarity).
Molecular function
Calcium channel, Ion channel, Voltage-gated channel
More Types Infomation
- Rabbit Anti-CACNB3 Polyclonal Antibody (MRO-1705-CN) (MRO-1705-CN)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, FC
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For Research Use Only. Not For Clinical Use.