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CAMK2B
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enriched (Bipolar cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enriched (SCLC-21H)
Interaction
CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other (PubMed:14722083, Ref.19). Interacts with SYNGAP1 and CAMK2N2 (By similarity). Interacts with MPDZ (PubMed:15312654). Interacts with FOXO3 (By similarity). Interacts (when in a kinase inactive state not associated with calmodulin) with ARC; leading to target ARC to inactive synapses (By similarity). Interacts with CAMK2N1; this interaction requires CAMK2B activation by Ca(2+) (By similarity).
Molecular function
Actin-binding, Calmodulin-binding, Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase
More Types Infomation
Related Signaling Pathways
cAMP Signaling Pathway
Canonical Wnt Signaling Pathway
ErbB Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Related Diseases
Amphetamine Addiction
Cushing Syndrome
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, IHC, WB
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC-P, WB
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, ICC, FC
-
- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: WB
-
- Derivation: Mouse
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG1
- Application: IHC
-
- Derivation: Mouse
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG1
- Application: IHC
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1
- Application: WB
-
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: IHC-P, IF
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- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: IHC-P, IF
- Mouse Anti-CAMK2B Recombinant Antibody (VS3-WK1387) (VS3-WK1387)
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- Derivation: Mouse
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: IHC-p
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For Research Use Only. Not For Clinical Use.