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CAMK4

The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.
Protein class

Enzymes, Metabolic proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Early spermatids, Excitatory neurons, Oligodendrocyte precursor cells, Inhibitory neurons, Late spermatids, T-cells, Bipolar cells)

Immune cell specificity

Group enriched (naive CD4 T-cell, MAIT T-cell, T-reg, naive CD8 T-cell, memory CD4 T-cell, memory CD8 T-cell)

Cell line specificity

Cell line enhanced (HDLM-2, JURKAT, MOLT-4, SH-SY5Y)

Interaction

Monomer (By similarity). Interacts with protein phosphatase 2A (PPP2CA/PPP2CB); the interaction is mutually exclusive with binding to Ca(2+)/calmodulin.

Molecular function

Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase

More Types Infomation

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