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CANT1

This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene.
Protein class

Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Intestinal goblet cells, Distal enterocytes, Syncytiotrophoblasts, Undifferentiated cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (OE19, T-47d)

Interaction

Monomer (PubMed:12234496, PubMed:15006348). Homodimer; dimerization is Ca(2+)-dependent (PubMed:16835225). Homodimer; disulfide-linked (membrane form) (PubMed:16835225).

Molecular function

Hydrolase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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