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CAPN1

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene.
Protein class

Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (RT4)

Interaction

Forms a heterodimer with a small (regulatory) subunit CAPNS1.

Molecular function

Hydrolase, Protease, Thiol protease

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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