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CARD11
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Microglial cells, dendritic cells, B-cells, NK-cells, T-cells, Plasma cells, Pancreatic endocrine cells)
Immune cell specificity
Immune cell enriched (plasmacytoid DC)
Cell line specificity
Cell line enhanced (Daudi, K-562, RT4, U-698)
Interaction
Homodimer; disulfide-linked (PubMed:24224005). Homomultimer; polymerizes following activation, forming a nucleating helical template that seeds BCL10-filament formation via a CARD-CARD interaction (PubMed:24074955). Interacts (via CARD domain) with BCL10 (via CARD domain); interaction takes place following CARD11 activation and polymerization, leading to the formation of a filamentous CBM complex assembly (PubMed:11278692, PubMed:11356195, PubMed:27777308, PubMed:24074955, PubMed:31296852). Component of a CBM complex (CARD11-BCL10-MALT1) complex involved in NF-kappa-B activation (PubMed:28628108, PubMed:24074955). Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB (PubMed:17287217). Interacts (via PDZ domain) with DPP4 (via cytoplasmic tail) (PubMed:17287217).
More Types Infomation
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1, κ
- Application: ELISA, WB, IP, IF, IHC, FC
- Recombinant Anti-Human CARD11 Antibody scFv Fragment (MOB-1556z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: Neut, WB, FuncS
- Recombinant Anti-Human CARD11 Antibody Fab Fragment (MOB-1556z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, ELISA, FuncS
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IF, WB
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For Research Use Only. Not For Clinical Use.