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CCL8

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.
Protein class

Cancer-related genes

Predicted location

Secreted

Single cell type specificity

Cell type enriched (Smooth muscle cells)

Immune cell specificity

Immune cell enriched (classical monocyte)

Cell line specificity

Cell line enhanced (BJ hTERT+, BJ hTERT+ SV40 Large T+ RasG12V, EFO-21, HSkMC)

Interaction

Monomer or homodimer; in equilibrium.

Molecular function

Cytokine, Heparin-binding

More Types Infomation

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