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CCNB1
CCNB1 (Cyclin B1) is a Protein Coding gene. Diseases associated with CCNB1 include Thyroid Lymphoma and Adrenal Carcinoma. Among its related pathways are Mitotic Prometaphase and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include protein kinase binding and patched binding. An important paralog of this gene is CCNB2.
Protein class
Cancer-related genes, Plasma proteins, Transporters
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Extravillous trophoblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase. Interacts with CCNF; interaction is required for nuclear localization. Interacts with CDK5RAP3 (PubMed:15790566). Interacts with RFPL4A and UBE2A (By similarity). Interacts with INCA1 (PubMed:21540187).
Molecular function
Cyclin
More Types Infomation
- PE-A*01:01/Human CCNB1 (CSEYVKDIY) MHC Tetramer (MHC-LC4410)
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- Class: Class I
- Antigen: CCNB1
- Antigen Species: Human
- Peptide: CSEYVKDIY
- Conjugate: PE
- PE-B*58:01/Human CCNB1 (FAFVTDNTY) MHC Tetramer (MHC-LC4324)
-
- Class: Class I
- Antigen: CCNB1
- Antigen Species: Human
- Peptide: FAFVTDNTY
- Conjugate: PE
- PE-A*29:02/Human CCNB1 (FAFVTDNTY) MHC Tetramer (MHC-LC4323)
-
- Class: Class I
- Antigen: CCNB1
- Antigen Species: Human
- Peptide: FAFVTDNTY
- Conjugate: PE
- PE-B*57:01/Human CCNB1 (FAFVTDNTY) MHC Tetramer (MHC-LC4322)
-
- Class: Class I
- Antigen: CCNB1
- Antigen Species: Human
- Peptide: FAFVTDNTY
- Conjugate: PE
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: IF, IP, WB
- Rabbit Anti-CCNB1 Recombinant Antibody (clone CBACN-162) (MRO-0411-CN)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP
- Mouse Anti-CCNB1 Recombinant Antibody (clone C2-F2) (MRO-0410-CN)
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: WB, IF
- Rabbit Anti-CCNB1 Polyclonal Antibody (MRO-1798-CN) (MRO-1798-CN)
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC, ICC, IHC-P, IP, WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IF, IHC, IP, FuncS
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF, IP
-
- Derivation: Mouse
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: IHC
-
- Derivation: Mouse
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: IHC
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, ICC, FC
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC
-
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: IHC-P, IF
-
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: IHC-P, IF
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: ELISA, IHC
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