Loading...
CCR2
The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3.
Protein class
CD markers, G-protein coupled receptors, Human disease related genes
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Kupffer cells, dendritic cells, monocytes, Plasma cells, Macrophages)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Cell line enhanced (Karpas-707, THP-1, U-266/70, U-266/84)
Interaction
Interacts with ARRB1 (PubMed:9501202). Interacts (via extracellular N-terminal region) with beta-defensin DEFB106A/DEFB106B; this interaction may preferentially require specific tyrosine sulfation on CCR2 (PubMed:23938203). Interacts with NUP85; the interaction is required for CCR2 clusters formation on the cell membrane and CCR2 signaling (PubMed:15995708, 25283965). (Microbial infection) Binds to HIV-1 Tat.
Molecular function
G-protein coupled receptor, Receptor, Transducer
More Types Infomation
- Recombinant Human Anti-human CCR2 Antibody scFv Fragment (MHH-159-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: WB, IHC, FuncS
- Recombinant Human Anti-human CCR2 Antibody Fab Fragment (MHH-159-F(E))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: FC, WB, FuncS
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP, FuncS
- Recombinant Anti-human CCR2 Antibody scFv Fragment (MOB-159-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, FuncS
- Recombinant Anti-human CCR2 Antibody Fab Fragment (MOB-159-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: FC, ELISA, FuncS
- Recombinant Anti-human CCR2 Antibody (MOB-159)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, IF, FuncS
-
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: FC
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, FC, IP, IHC-Fr, IHC-P
- Rabbit Anti-CCR2 Recombinant Antibody (clone CBACN-101) (MRO-0264-CN)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, IP, FC
- Human Anti-CCR2 Recombinant Antibody (TAB-1510CL) (TAB-1510CL)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: FC
- Human Anti-CCR2 Recombinant Antibody (TAB-1509CL) (TAB-1509CL)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: FC
- Human Anti-CCR2 Recombinant Antibody (TAB-1508CL) (TAB-1508CL)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: FuncS
- Human Anti-CCR2 Recombinant Antibody (TAB-1515CL) (TAB-1515CL)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, FuncS
- Human Anti-CCR2 Recombinant Antibody (TAB-1514CL) (TAB-1514CL)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, FuncS
- Human Anti-CCR2 Recombinant Antibody (TAB-1513CL) (TAB-1513CL)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
- Human Anti-CCR2 Recombinant Antibody (TAB-1512CL) (TAB-1512CL)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
- Human Anti-CCR2 Recombinant Antibody (TAB-1511CL) (TAB-1511CL)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
- Human Anti-CCR2 Recombinant Antibody; scFv Fragment (TAB-1510CL-S(P)) (TAB-1510CL-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: FC
- Human Anti-CCR2 Recombinant Antibody; scFv Fragment (TAB-1509CL-S(P)) (TAB-1509CL-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: FC
- Human Anti-CCR2 Recombinant Antibody; scFv Fragment (TAB-1508CL-S(P)) (TAB-1508CL-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: FuncS
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
For Research Use Only. Not For Clinical Use.