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CD24

This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants.
Protein class

Cancer-related genes, CD markers, Disease related genes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Exocrine glandular cells, Pancreatic endocrine cells, Distal tubular cells, Distal enterocytes, Glandular and luminal cells)

Immune cell specificity

Group enriched (eosinophil, memory B-cell, naive B-cell)

Cell line specificity

Cell line enhanced (NTERA-2, RPTEC TERT1, RT4, SK-BR-3)

Interaction

Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line, LYN in the erythroleukemia cell line K-562 and in Burkitt's lymphoma.

More Types Infomation

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