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CD86

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This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.

Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, WB, IF, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
IP, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB, ELISA, IHC, FuncS
Type:
Humanized antibody
Derivation:
Chimeric (Mouse/human)
Type:
Chimeric antibody (mouse/human)
Application:
IHC
Species Reactivity:
Human
Type:
IgG1
Application:
WB, Neut, FC, CyTOF
Species Reactivity:
Human
Type:
IgG1
Application:
WB, FC, CyTOF, Neut
Species Reactivity:
Human
Type:
IgG1
Application:
Neut, FC
Species Reactivity:
Human
Type:
IgG2b, κ
Application:
FC, FuncS, Neut
Species Reactivity:
Mouse
Type:
IgG2b, κ
Application:
FC, IHC-Fr, IP, BL
Species Reactivity:
Mouse
Type:
IgG2a, κ
Application:
FC, BL, IF, IHC, IP
Species Reactivity:
Mouse
Type:
IgG2
Application:
BL, FC, IHC-Fr, IP
Species Reactivity:
Mouse
Type:
IgG2b, κ
Application:
FC, FuncS, Neut
Species Reactivity:
Rat
Type:
IgG1
Application:
Neut
Species Reactivity:
Mouse
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Mouse
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Mouse
Application:
Cytotoxicity assay, Functional assay
Species Reactivity:
Human
Type:
ADCC enhanced antibody
Scaffold Name:
CTLA-4 (extracellular domain)
Target:
CD86
Species Reactivity:
Human
Derivation:
Phage display
Type:
Humanized antibody
Type:
Humanized antibody
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