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CDC25A
CDC25A (Cell Division Cycle 25A) is a Protein Coding gene. Diseases associated with CDC25A include Breast Cancer. Among its related pathways are Metabolism of proteins and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein tyrosine phosphatase activity. An important paralog of this gene is CDC25B.
Protein class
Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cardiomyocytes, Late spermatids, Early spermatids, Spermatogonia)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Low cell line specificity
Interaction
Interacts with CCNB1/cyclin B1. Interacts with YWHAE/14-3-3 epsilon when phosphorylated. Interacts with CUL1 specifically when CUL1 is neddylated and active. Interacts with BTRC/BTRCP1 and FBXW11/BTRCP2. Interactions with CUL1, BTRC and FBXW11 are enhanced upon DNA damage. Interacts with PIM1. Interacts with CHEK2; mediates CDC25A phosphorylation and degradation in response to infrared-induced DNA damages. Interacts with HSP90AB1; prevents heat shock-mediated CDC25A degradation and contributes to cell cycle progression (PubMed:22843495).
Molecular function
Hydrolase, Protein phosphatase
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-Fr, IHC-P, IP, WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, IP
- Chicken Anti-CDC25a Polyclonal IgY (BRD-0108MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, IP
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For Research Use Only. Not For Clinical Use.