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CDK3
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Ionocytes, Granulosa cells, Breast glandular cells, Glandular and luminal cells, Breast myoepithelial cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Low cell line specificity
Interaction
Interacts with CABLES1 and CABLES2 (By similarity). Interacts with ATF1. Binding to CCNC/cyclin-C promotes RB1 phosphorylation.
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
More Types Infomation
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- Species Reactivity: Human
- Application: IHC-P, WB
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For Research Use Only. Not For Clinical Use.