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CHD1L

This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Overexpression of this gene has been linked to several types of cancers.
Protein class

Enzymes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Oligodendrocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Interacts (via macro domain) with PARP1; interacts only when PARP1 is poly-ADP-ribosylated (PARylated) (PubMed:19661379, PubMed:29220653). Interacts with CIAO1 (PubMed:23891004).

Molecular function

Helicase, Hydrolase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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