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CLCA1

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.
Protein class

Transporters

Predicted location

Secreted

Single cell type specificity

Cell type enriched (Intestinal goblet cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BEWO, NB-4, RPMI-8226, SH-SY5Y, U-2197)

Molecular function

Hydrolase, Metalloprotease, Protease

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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