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COMP
May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Late spermatids, Early spermatids, Glandular and luminal cells, Fibroblasts, Basal respiratory cells, Spermatocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (fHDF/TERT166)
Interaction
Pentamer; disulfide-linked (PubMed:32686688). Exists in a more compact conformation in the presence of calcium and shows a more extended conformation in the absence of calcium (PubMed:19276170). Interacts with ITGB3, ITGA5 and FN1. Binding to FN1 requires the presence of divalent cations (Ca(2+), Mg(2+) or Mn(2+)). The greatest amount of binding is seen in the presence of Mn(2+) (PubMed:16051604, PubMed:12225811). Interacts with MATN1, MATN3, MATN4 and ACAN (PubMed:15075323, PubMed:17588949). Binds heparin, heparan sulfate and chondroitin sulfate. EDTA dimishes significantly its binding to ACAN and abolishes its binding to MATN3, MATN4 and chondroitin sulfate (PubMed:17588949). Interacts with collagen I, II and IX, and interaction with these collagens is dependent on the presence of zinc ions (PubMed:11084047). Interacts with ADAMTS12 (PubMed:16611630). Interacts with ITGA7 (By similarity).
Molecular function
Heparin-binding
More Types Infomation
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- Species Reactivity: Rat
- Type: Rat scFv
- Application: ELISA, FuncS
- Rat Anti-COMP Recombinant Antibody (Clone 15A) (PABS-0006)
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- Species Reactivity: Rat
- Type: Rat IgG
- Application: ELISA, FuncS
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, FC
- Mouse Anti-COMP Recombinant Antibody (clone 2G5) (MOB-1857z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA
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- Species Reactivity: Rat
- Type: Rat Fab
- Application: ELISA, FuncS
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For Research Use Only. Not For Clinical Use.