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CREB1

Engineered Antibody
CREB1 (CAMP Responsive Element Binding Protein 1) is a Protein Coding gene. Diseases associated with CREB1 include Histiocytoma, Angiomatoid Fibrous and Melanoma Of Soft Tissue. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and enzyme binding. An important paralog of this gene is CREM.
Protein class

Cancer-related genes, Disease related genes, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enriched (Early spermatids)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts, through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on Ser-119, binds CREBBP (By similarity). Interacts with CREBL2; regulates CREB1 phosphorylation, stability and transcriptional activity (By similarity). Interacts (phosphorylated form) with TOX3. Interacts with ARRB1. Binds to HIPK2. Interacts with SGK1. Interacts with TSSK4; this interaction facilitates phosphorylation on Ser-119 (PubMed:15964553). Forms a complex with KMT2A and CREBBP (PubMed:23651431). (Microbial infection) Interacts with hepatitis B virus/HBV protein X. (Microbial infection) Interacts with HTLV-1 protein Tax.

Molecular function

Activator, DNA-binding

More Types Infomation
Related Signaling Pathways
cAMP Signaling Pathway cAMP Signaling Pathway
MAPK Signaling Pathway MAPK Signaling Pathway
PPAR Signaling Pathway PPAR Signaling Pathway
TLR Signaling Pathway TLR Signaling Pathway
TNF Signaling Pathway TNF Signaling Pathway
Related Diseases
Prostate Cancer Prostate Cancer
Morphine Addiction Morphine Addiction
Cocaine Addiction Cocaine Addiction
Amphetamine Addiction Amphetamine Addiction
Alcoholism Alcoholism
Cushing Syndrome Cushing Syndrome

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