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CRKL
CRKL (CRK Like Proto-Oncogene, Adaptor Protein) is a Protein Coding gene. Diseases associated with CRKL include Chromosome 22Q11.2 Deletion Syndrome, Distal and Leukemia, Chronic Myeloid. Among its related pathways are RET signaling and Chronic myeloid leukemia. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is CRK.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (K-562)
Interaction
Interacts with tyrosine-phosphorylated EPOR and INPP5D/SHIP1 (PubMed:11443118). Interacts with DOCK2 and DOCK5 via its first SH3 domain (PubMed:12393632, PubMed:19004829). Interacts with phosphorylated CBLB and IRS4 (PubMed:10022120, PubMed:9614078).
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IHC-P, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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For Research Use Only. Not For Clinical Use.