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CSF1

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants.
CSF1
Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, RAS pathway related proteins

Predicted location

Intracellular, Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (granulocytes, Skeletal myocytes, Sertoli cells, Fibroblasts, Hepatic stellate cells)

Immune cell specificity

Group enriched (eosinophil, basophil)

Cell line specificity

Cell line enhanced (ASC diff, BJ hTERT+, GAMG, HHSteC, HSkMC, hTERT-RPE1)

Interaction

Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R.

Molecular function

Cytokine, Growth factor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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