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CXCL16

Chemokine (C-X-C motif) ligand 16 (CXCL16) is a small cytokine belonging to the CXCchemokine family. Larger than other chemokines (with 254 amino acids), CXCL16 is composed of a CXC chemokine domain, a mucin-like stalk, a transmembrane domain and a cytoplasmic tail containing a potential tyrosine phosphorylation site that may bind SH2.[1] These are unusual features for a chemokine, and allow CXCL16 to be expressed as a cell surface bound molecule, as well as a soluble chemokine.
Protein class

Transporters

Predicted location

Intracellular, Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enriched (Late spermatids)

Immune cell specificity

Group enriched (non-classical monocyte, intermediate monocyte, neutrophil, classical monocyte, myeloid DC)

Cell line specificity

Cell line enhanced (A-431, CACO-2, CAPAN-2, HaCaT, T-47d)

Molecular function

Cytokine

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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