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CXCR2

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The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.

Type:
Humanized antibody
Application:
ELISA
Type:
Humanized antibody
Application:
ELISA
Derivation:
Phage display library
Type:
Human antibody
Application:
ELISA
Derivation:
Phage display library
Type:
Human antibody
Application:
ELISA
Derivation:
Phage display library
Type:
Human antibody
Application:
ELISA
Derivation:
Phage display library
Type:
Human antibody
Application:
ELISA
Derivation:
Phage display library
Type:
Human antibody
Application:
ELISA
Derivation:
Phage display library
Type:
Human antibody
Application:
ELISA
Type:
Single domain antibody
Application:
FC
Type:
Single domain antibody
Application:
FC
Type:
Single domain antibody
Application:
FC
Species Reactivity:
Human
Type:
Mouse antibody
Application:
ELISA, ELISA, FC, IHC-P, WB
Species Reactivity:
Human
Type:
IgG2
Application:
FC, IHC, Neut
Species Reactivity:
Human
Type:
IgG2a
Application:
IHC-Fr, Neut, FC
Species Reactivity:
Human
Type:
IgG2a
Application:
FC, IHC, CyTOF, Neut
Species Reactivity:
Human
Type:
IgG2a
Application:
Neut, FC
Species Reactivity:
Mouse
Type:
IgG2
Application:
FC, Neut
Species Reactivity:
Mouse
Type:
IgG2a
Application:
FC, CyTOF, Neut
Species Reactivity:
Mouse
Type:
IgG2
Application:
Neut, FC, IHC-P, CyTOF
Derivation:
Humanized
Species Reactivity:
Human, Cynomolgus, Mouse
Type:
Humanized scFv
Application:
ELISA, FC, FunS
Derivation:
Chimeric (Mouse/Human)
Species Reactivity:
Human
Type:
Chimeric (Mouse/Human) IgG
Application:
ELISA
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