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CXCR4

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CXCR-4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. CXCR4 is one of several chemokine receptors that HIV can use to infect CD4+ T cells. HIV isolates that use CXCR4 are traditionally known as T-cell tropicisolates. Typically, these viruses are found late in infection. It is unclear as to whether the emergence of CXCR4-using HIV is a consequence or a cause of immunodeficiency.

Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, IP, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
FC, IP, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
ELISA, IP, FuncS
Derivation:
human
Species Reactivity:
Human
Type:
IgG4 - kappa
Application:
IP, IF, FuncS, FC, Neut, ELISA, ICC
Target:
CXCR4
Linker:
p-acetyl phenylalanine (pAcF)
Drug:
MMAF (Monomethyl auristatin F)
Target:
CD184
Linker:
PEG-S-4FB linker
Drug:
dasatinib
Target:
CD184
Linker:
disulfide-cleavable linkers
Drug:
dasatinib
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Derivation:
Humanized
Species Reactivity:
Human
Type:
Single Domain Antibody
Derivation:
Phage display library
Type:
Human antibody
Type:
Humanized antibody
Application:
cAMP Assay
Type:
Humanized antibody
Application:
cAMP Assay
Type:
Humanized antibody
Application:
cAMP Assay
Type:
Human antibody
Application:
FC
Type:
Human antibody
Application:
WB, ELISA
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