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DDX39B
This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene. [provided by RefSeq, Feb 2011]
Protein class
Enzymes, Plasma proteins, Transporters
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HEK93, hTERT-HME1, K-562, NB-4)
Interaction
Homodimer, and heterodimer with DDX39A (PubMed:11675789, PubMed:15833825, PubMed:14667819). Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have dynamic structure involving ATP-dependent remodeling; in the complex bridges ALYREF/THOC4 and the THO complex, and, in a ATP-dependent manner, ALYREF/THOC4 and SARNP/CIP29 (PubMed:11675789, PubMed:15833825, PubMed:14667819, PubMed:15998806, PubMed:17984224, PubMed:20844015, PubMed:23299939). Component of the spliceosome. Interacts directly with U2AF2 (PubMed:9242493). Interacts with RBM8A, RNPS1 and SRRM1, FYTTD1/UIF, THOC1, MX1 and POLDIP3 (PubMed:12944400, PubMed:15870275, PubMed:19836239, PubMed:21859714, PubMed:22928037). Interacts with LUZP4 (PubMed:25662211). (Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL69.
Molecular function
Helicase, Hydrolase, RNA-binding
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: FC, WB, IHC-P, ICC, IF
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- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: WB, ICC, IHC
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For Research Use Only. Not For Clinical Use.