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DEF6
DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids, Hofbauer cells, NK-cells, T-cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (JURKAT, MOLT-4, NB-4, REH, THP-1, U-937)
Interaction
Interacts with ZAP70 (By similarity). Interacts with IRF4, activated RAC1 and F-actin. Both the phosphorylated and non-phosphorylated forms bind phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3).
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IP, FC
- Recombinant Mouse Anti-Human DEF6 Antibody (MOB-1084MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P
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For Research Use Only. Not For Clinical Use.