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DES
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Cardiomyocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HSkMC, LHCN-M2, NB-4, RH-30)
Interaction
Homomer (PubMed:21135508). Interacts with DST (By similarity). Interacts with MTM1 (PubMed:21135508). Interacts with EPPK1; interaction is dependent of higher-order structure of intermediate filament (PubMed:16923132). Interacts with CRYAB (PubMed:28470624). Interacts with NEB (via nebulin repeats 160-164) (PubMed:23615443). Interacts (via rod region) with NEBL (via nebulin repeats 1-5) (PubMed:27733623). Interacts with ASB2 isoform 1; the interaction targets DES for proteasomal degradation (By similarity).
Molecular function
Muscle protein
More Types Infomation
- Rabbit Anti-DES Recombinant Antibody (clone AFY0058) (MOR-0087-FY)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: ICC, IHC-P, WB
- Rabbit Anti-DES Recombinant Antibody (clone CBACN-194) (MRO-0473-CN)
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- Species Reactivity: Human, Mouse, Rat, Zebrafish
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
- Mouse Anti-DES Recombinant Antibody (clone 3-F7) (MRO-0472-CN)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, IF, IHC, FC
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: ICC/IF, IHC-Fr IHC-P, WB
- Mouse Anti-DES Recombinant Antibody (clone 25C5) (MOB-1487z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, IHC
- Rabbit Anti-DES Polyclonal Antibody (MRO-1813-CN) (MRO-1813-CN)
-
- Species Reactivity: Human, Mouse, Zebrafish
- Type: Rabbit IgG
- Application: WB, IF, IHC
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC-P
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgM, κ
- Application: WB
-
- Species Reactivity: Chicken, Human, Mouse, Rabbit, Rat, Pig
- Type: Mouse IgG1
- Application: IHC-Fr, IHC-P, WB
-
- Species Reactivity: Human, Hamster, Rat, Chicken
- Type: Mouse IgG1
- Application: ICC, IHC-Fr, IHC-P, WB
- Rabbit Anti-DES Recombinant Antibody (VS3-CJ719) (VS3-CJ719)
-
- Species Reactivity: Human, Mouse, Rat, Zebrafish
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, FC
- Mouse Anti-DES Recombinant Antibody (VS3-CJ718) (VS3-CJ718)
-
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: IHC
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC
-
- Species Reactivity: Chicken, Dog, Hamster, Human, Mouse, Rabbit, Rat, Pig, Zebrafish
- Type: Mouse IgG2b
- Application: ICC, IHC-Fr
-
- Derivation: Mouse
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG1
- Application: IHC
-
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: IF/ICC, IHC-P
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: IHC-P, IF
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: IHC-P, IF
- Mouse Anti-DES Recombinant Antibody (VS4-WK141) (VS4-WK141)
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: ELISA, IHC
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For Research Use Only. Not For Clinical Use.